Scientist I, Upstream MSAT

Job Title: Scientist I, Upstream MSAT

Location: Framingham, MA

About the Job

We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families.

Sanofi’s Global MSAT (Manufacturing Sciences, Analytics, and Technology) acts as a crucial link between our R&D and Manufacturing entities, playing an instrumental role in enhancing our current portfolio and delivering future launches of high-quality and innovative drugs and vaccines. Global MSAT is a beacon of innovation and process excellence in Manufacturing, this includes guiding the journey of new products from their launch to commercial success, being at the forefront of Data Sciences and Digitalization.  Join a team of talented and passionate international experts, scientists, and project leaders dedicated to inventing, designing, industrializing, and implementing cutting-edge industrial chemical and biological processes, analytical methods, and process modeling to successfully launch 3 to 5 new products by year.

The Scientist I position is part of the Upstream team in the Recombinant Drug Substance (DS) function within global MSAT and is based at the Mammalian Platform hub in Framingham, MA. The Recombinant DS function within global MSAT is the owner of Life Cycle Management (LCM) of DS processes. Implementation of second-generation processes is one of the top performance enablers for Sanofi’s biologics manufacturing network and integral to LCM.  We deliver innovative, robust, and cost-effective next generation processes. In recent years we have successfully established second-generation manufacturing mammalian processes with a continuous process platform. The function is responsible for tech transfer, process validation, dossier preparation, & PAI support to enable launch of new and LCM products. We are pursuing future innovations such as digital labs, factory of the future, and advanced-analytics-based process understanding and control.

The successful candidate will work with a group of scientists and engineers responsible for development & characterization of next generation cell culture processes, technology transfer to a diverse network of manufacturing facilities, and support of advanced manufacturing investigations and process improvements for commercial products. We are looking for a candidate with excellent scientific and communication skills. This individual will work in a fast-paced, team environment, collaborating with colleagues across functions in the organization to solve a wide range of complex problems in creative and practical ways.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Design and conduct experiments, interpret data, and present results to department and project teams.

• Analyze process development and commercial manufacturing data in support of the MSAT mission; with the aim of improving process robustness, building process understanding and developing next-generation processes for monoclonal antibodies and recombinant proteins.

• Lead a small project team for LCM Upstream process improvements and implementation in manufacturing.

• Contribute to technology transfer, represent the Upstream team across groups and organizations, and lead efforts to address process fit.

• Contribute to technical investigations of complex deviations in manufacturing.

• Contribute to establishment of best practices and technical ways of working within development and manufacturing teams.

• Mentor and support junior staff and build a culture of support and collaboration.

• Collaborate with other scientists/engineers across the biologics manufacturing network within Sanofi and with partnership organizations.

• Responsible for internal documentation and preparation of technical reports required for regulatory documents. May support authoring of regulatory filings.

About You

Experience:

• Bachelor’s degree in life science, or engineering, or related disciplines with 5 years’ relevant industry experience OR Master's degree with 3 years’ relevant industry experience OR PhD with 0-year industry experience required.

• Hands-on experience at laboratory, pilot, or manufacturing scale for biologics products.

Soft and technical skills:

• Excellent scientific background, technical writing, and presentations skills.

• Highly motivated individual with excellent attention to detail, having a proven ability to work independently and on cross-functional and cross-site teams.

• Flexible with ability to adjust to a fast-paced, goal-oriented environment and willingness to expand and broaden skills.

• Strong experience in one or more areas of upstream process development; process transfer, process scale-up/scale-down, validation, and continuous process verification as applied to mammalian-expressed proteins.

• Experience with statistical analysis software.

• Knowledgeable in additional cell culture systems and modalities, such as insect cell culture, or gene / cell therapy.

Languages:

• English

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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