Job title: Sr Principal scientist, Immune tolerance and autoimmunity

• Location: Vitry-Sur-Seine
• Grade: L3
• Hiring Manager: Rami LISSILAA

About the job

As Sr Principal scientist within our Immune tolerance and autoimmunity cluster, you’ll develop innovative therapeutic approaches and identify novel targets in autoimmunity, leveraging your expertise to design groundbreaking preclinical studies, mentor team members, and collaborate across functions to advance transformative science for patients. Ready to get started?

Sanofi's Immunology and Inflammation Research is establishing an Immune Regulation and Autoimmune Diseases center of excellence at Vitry, seeking a Sr Principal Scientist with immunology expertise. You'll contribute to drug discovery and lead research within the immune tolerance cluster, focusing on identifying novel therapeutic concepts that could transform autoimmune disease treatment. The team will target pathogenic immune pathways, explore disruptive modalities, and develop translational assays for screening therapeutic candidates.

Looking for an environment that values enthusiasm, collaboration, and innovation for patients? Join us to transform Immunology research into real-world solutions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. 

Main responsibilities:

• Lead innovative projects and research activities to develop differentiated and high value projects and manage research programs in the emerging area of immune tolerance, immune regulation and autoimmunity
• Advance cutting-edge science to enable continual innovation through the identification of new targets and disruptive therapeutic approaches in the field of Immune tolerance and autoimmunity
• Apply scientific expertise and judgement to initiate, design, direct and execute preclinical study experiments and/or studies in support of research project goals in a time sensitive manner
• Act as an impactful contributor and leader of project teams and transverse and cross-functional initiatives
• Work across R&D organization to test and advance innovative projects, hypotheses and methodologies: encourages curiosity and challenges the status quo in order to foster innovation
• Mentor, motivate and train a laboratory team, including Sr technicians, scientists and eventually PhD student and post-docs
• Provide strong scientific and technical leadership in the design and execution of a broad range of complex immune tolerance assays to elucidate mechanism of action and understand disease biology
• Participate to the evaluation of preclinical/clinical-stage in-licencing and collaboration opportunities
• Create and maintain a work environment in which scientific excellence and innovation in immunology are fostered

About you

Experience:

• Leading-edge knowledge of Immunology including T/B cell biology or innate immunity and relevant experience in the immunology/inflammation related disease areas
• Demonstrated ability to identify new targets using genetic, transcriptomics or other bioinformatics analysis is desirable
• Hands-on manager of people at different levels including technicians, PhD, scientists
• Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators

Soft and technical skills:

• Excellent interpersonal and communication skills: impactful oral and written communication
• Strong scientific curiosity and rigor, excellent interpersonal, technical and analytic skills, high ethical standards
• Fast learner, flexibility to rapidly change priorities and deadlines and ability to lead others through change in a dynamic, fast paced industry and work environment

Education:

• PhD level in Immunology, with a relevant academic research (post doc) and/or industrial experience

Languages:

• English, (French desirable)

Why choose us?

• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science
• Help improve the lives of millions of people globally by making drug development quicker and more effective
• Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs
• Join a workplace where diversity, equity, and inclusion are at the core, with Employee Resource Groups and leadership programs that celebrate every voice
• Achieve genuine work-life balance in a supportive R&D environment

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